Gene information
Official symbol CCR5
Official full name C-C motif chemokine receptor 5
Gene type protein-coding gene
Chromosome3p21.31
Alias symbolCKR-5; CC-CKR-5; CKR5; CD195; IDDM22
Previous symbolCMKBR5
Gene familyCD molecules; C-C motif chemokine receptors
Resources
Entrez Gene 1234
HGNC HGNC:1606
Ensembl ENSG00000160791
Vega OTTHUMG00000133481
UCSC uc062izs.1
GO terms: 47 records
GO Description Category LogP Number of genes Detail
GO:0000165 MAPK cascade GO Biological Processes -7.43732657 14 More
GO:0001618 virus receptor activity GO Molecular Functions -7.88412825 17 More
GO:0001637 G protein-coupled chemoattractant receptor activity GO Molecular Functions -4.13020121 7 More
GO:0001653 peptide receptor activity GO Molecular Functions -6.43798881 12 More
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0002407 dendritic cell chemotaxis GO Biological Processes -5.31723275 7 More
GO:0004435 phosphatidylinositol phospholipase C activity GO Molecular Functions -7.32266784 10 More
GO:0004620 phospholipase activity GO Molecular Functions -8.28406161 12 More
GO:0004629 phospholipase C activity GO Molecular Functions -6.96326292 10 More
GO:0004896 cytokine receptor activity GO Molecular Functions -9.30297759 21 More
GO:0004950 chemokine receptor activity GO Molecular Functions -4.13020121 7 More
GO:0006816 calcium ion transport GO Biological Processes -5.55009887 27 More
GO:0006968 cellular defense response GO Biological Processes -1.67086927 6 More
GO:0007204 positive regulation of cytosolic calcium ion concentration GO Biological Processes -15.6883547 39 More
GO:0008081 phosphoric diester hydrolase activity GO Molecular Functions -7.01687804 10 More
GO:0008528 G protein-coupled peptide receptor activity GO Molecular Functions -6.62401664 12 More
GO:0009897 external side of plasma membrane GO Cellular Components -28.0033937 46 More
GO:0016032 viral process GO Biological Processes -8.84449931 34 More
GO:0016298 lipase activity GO Molecular Functions -10.3255371 15 More
GO:0016493 C-C chemokine receptor activity GO Molecular Functions -4.51081372 7 More
GO:0016788 hydrolase activity, acting on ester bonds GO Molecular Functions -4.57583420 56 More
GO:0019058 viral life cycle GO Biological Processes -10.6409496 31 More
GO:0019722 calcium-mediated signaling GO Biological Processes -11.6647584 29 More
GO:0019932 second-messenger-mediated signaling GO Biological Processes -19.1717114 46 More
GO:0019956 chemokine binding GO Molecular Functions -7.24411974 11 More
GO:0019957 C-C chemokine binding GO Molecular Functions -4.37707433 7 More
GO:0030001 metal ion transport GO Biological Processes -7.54203733 26 More
GO:0032496 response to lipopolysaccharide GO Biological Processes -45.257773 87 More
GO:0036314 response to sterol GO Biological Processes -7.24411974 11 More
GO:0036336 dendritic cell migration GO Biological Processes -5.26554247 8 More
GO:0042578 phosphoric ester hydrolase activity GO Molecular Functions -4.79997475 34 More
GO:0044000 movement in host GO Biological Processes -9.40214314 25 More
GO:0044409 entry into host GO Biological Processes -10.3666963 14 More
GO:0046718 viral entry into host cell GO Biological Processes -10.4786216 14 More
GO:0051282 regulation of sequestering of calcium ion GO Biological Processes -7.93009971 22 More
GO:0051701 biological process involved in interaction with host GO Biological Processes -10.6054189 28 More
GO:0070723 response to cholesterol GO Biological Processes -8.11481650 11 More
GO:0071216 cellular response to biotic stimulus GO Biological Processes -28.1549742 59 More
GO:0071219 cellular response to molecule of bacterial origin GO Biological Processes -28.3848077 56 More
GO:0071222 cellular response to lipopolysaccharide GO Biological Processes -26.0381191 52 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0097305 response to alcohol GO Biological Processes -17.4096682 46 More
GO:0098552 side of membrane GO Cellular Components -22.4625650 48 More
GO:0098660 inorganic ion transmembrane transport GO Biological Processes -4.47276690 21 More
GO:0140272 exogenous protein binding GO Molecular Functions -8.63789613 18 More
GO:0140375 immune receptor activity GO Molecular Functions -8.53513203 25 More
GO:2000106 regulation of leukocyte apoptotic process GO Biological Processes -11.3593886 22 More
KEGG pathways: 3 records
KEGG Description Category LogP Number of genes Detail
hsa05145 Toxoplasmosis KEGG Pathway -13.6215025 17 More
hsa05170 Human immunodeficiency virus 1 infection KEGG Pathway -2.98955463 9 More
hsa05203 Viral carcinogenesis KEGG Pathway -1.94955729 7 More
Drug-Gene interaction
view
Related drugs: 11 records
Drug name Interaction type Source PMID View
aplaviroc hydrochloride antagonist ChemblInteractions view
azd5672 antagonist ChemblInteractions view
cenicriviroc antagonist TdgClinicalTrialChemblInteractionsTTD view
chembl207004 antagonist DTCTTD 26451468 view
incb-9471 antagonist ChemblInteractionsTTD view
leronlimab antibodyantagonist ChemblInteractionsTTD 1113427031903790 view
maraviroc antagonist DTCTdgClinicalTrialChemblInteractionsTENDPharmGKBTTD 162983451969247619098484117523521713928417016423 view
pf-04634817 antagonist ChemblInteractions view
pf-232798 TTD view
vicriviroc antagonist TdgClinicalTrialTTD 1724306518495779 view
vicriviroc maleate antagonist ChemblInteractions view
Related studies: 6 records
Molecular factor Omics type Application Objective MI type Reference
NC_000003.12:g.[46357717G>A;46373456_46373487del] genomics myocardial infarction[diagnosis] myocardial infarction Kallel A et al. Clin Biochem. 2012
NM_000579.4:c.-301+246A>G genomics acute myocardial infarction[diagnosis] acute myocardial infarction Singh N et al. Mol Biol Rep. 2012
NM_001394783.1:c.554_585del genomics myocardial infarction[diagnosis] myocardial infarction Gonzalez P et al. Genes Immun. 2001
NM_001394783.1:c.554_585del genomics myocardial infarction[diagnosis] myocardial infarction Karaali ZE et al. Mol Biol Rep. 2010
NM_001394783.1:c.554_585del genomics acute myocardial infarction[diagnosis] acute myocardial infarction Singh N et al. Mol Biol Rep. 2012
NM_001394783.1:c.554_585del genomics myocardial infarction[diagnosis] myocardial infarction Kallel A et al. Clin Biochem. 2012
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